¿ì¸®¾Æ±â´åÄÄ - Ä¡¾Æ°ü¸® °¨±â µ¶°¨ õ½Ä Ȳ»ç
    
    
ÀÚµ¿·Î±×ÀÎ
°Ç°­ °Ô½ÃÆÇ
¾Æ±â °Ç°­
¾Æ±â ½Åü
¾Æ±â°¡ ¾ÆÆÄ¿ä?


[ À¯¾Æ°Ç°­ À̾߱â ]
 
ÀÛ¼ºÀÏ : 15-03-09 02:22
¼¼Æ÷ Cells > Áٱ⼼Æ÷
 ±Û¾´ÀÌ : ¿ì¸®¾Æ±â
Á¶È¸ : 4,992  
   http://kimkwag.cafe24.com/stem_cell/Stemcell_sum.html [1274]
Áٱ⼼Æ÷ ÁÖ¿ä ³»¿ë
 
¹è¾ÆÁٱ⼼Æ÷
¹è¾ÆÁٱ⼼Æ÷
¹è¾ÆÁٱ⼼Æ÷
¼ºÃ¼Áٱ⼼Æ÷ => À¯»ç¹è¾ÆÁٱ⼼Æ÷
¼ºÃ¼Áٱ⼼Æ÷
¼öÁ¤¶õ
ü¼¼Æ÷ÇÙÀ̽Ä
´Ü¼º»ý½Ä
À¯ÀüÀÚµµÀÔ
°ñ¼ö, Á¦´ëÇ÷
 
1996 µ¹¸®º¹Á¦
(·Î½½¸° ¿¬±¸¼Ò)
 
 
 
1998
Àΰ£¹è¾ÆÁٱ⼼Æ÷
(À©½ºÄܽŴë)
1998
Àΰ£¹è¾Æº¹Á¦
(°æÈñ´ë)
 
 
1998
Á¦´ëÇ÷À̽Ä
ÇÁ Dr. Gluckman
2000 ¹è¾ÆÁٱ⼼Æ÷ÁÖ NIH ¿¡ µî·Ï(MzMedi)
2001
Àΰ£¹è¾Æº¹Á¦(ACT)
 
 
 
 
2004 Àΰ£º¹Á¦¹è¾ÆÁٱ⼼Æ÷ÁÖ?
(Ȳ±³¼ö)
2004 Parthenogenic mouse(Kono)
 
 
 
2005 ȯÀÚ¸ÂÃãÇü SCNT-hESC ?
(Ȳ±³¼ö)
 
2006 Áã À¯µµº¹¼öºÐÈ­Áٱ⼼Æ÷(Yamanaka)
 
 
2007 ¿ø¼þÀÌü¼¼Æ÷º¹Á¦Áٱ⼼Æ÷ÁÖ
(¹ÌÅ»¸®Æ÷ÇÁ ¹Ú»ç)
2007 Hwang¡¯s SCNT-hESC-1 = Parthenote(Daley)
Human iPS(Yamanaka,  Daley)
 

 
Regenerative Medicine
Tissue Engineering
Cell Therapy(Transplantation Medicine) – ÀÇÇÐÀÇ ¡®Paradigm¡¯À» ¹Ù²Û´Ù?
 
 
 
Àΰ£ÀÇ ¼¼Æ÷ ¼ö 60Á¶
Àΰ£ÀÇ ¼¼Æ÷ Á¾·ù 220 °¡Áö(210~274 kinds)
 
Àç»ýºÒ´É ¼¼Æ÷ – ½Å°æ¼¼Æ÷, ½É±Ù¼¼Æ÷ (¹è¾ÆÁٱ⼼Æ÷ ¿ì¼± Àû¿ë ´ë»ó)
Àç»ý°¡´É ¼¼Æ÷ – ÇǺμ¼Æ÷, Á¡¸·¼¼Æ÷ µî
Àç»ý°ï¶õ ¼¼Æ÷ – °£¼¼Æ÷                        
 
 
(1) 1998 À©½¼ÄܽŠ´ë Thomson ¹Ú»ç ÆÀÀÇ Àΰ£¹è¾ÆÁٱ⼼Æ÷ »ý¼º
³Ãµ¿¼öÁ¤¶õ¿¡¼­ ¹è¹ÝÆ÷·Î ¹ß»ý½ÃÄÑ ICMÀ» ²¨³» °è´ë¹è¾çÇÏ¿© hES cell »ý¼º
 
 
(2) 2004 Ȳ±³¼ö ÆÀ ü¼¼Æ÷º¹Á¦ Àΰ£¹è¾ÆÁٱ⼼Æ÷ÁÖ È®¸³ ÁÖÀå
2007³â Laley ¹Ú»ç º¸°í¼­¿¡¼­ ´Ü¼º»ý½Ä¹è¾ÆÁٱ⼼Æ÷·Î È®½Ç½Ã µÊ            
 
 
(3) 2004 °í³ë ¹Ú»ç ÆÀ ó³à»ý½Ä Áã ź»ý
Á¤ÀÚ¼¼Æ÷¿¡¼­ Ç¥ÇöµÇÁö ¾Ê´Â H19 À¯ÀüÀÚ¸¦ Á¦°ÅÇÏ°í ³­ÀÚ¿¡¼­ Ç¥ÇöµÇÁö ¾Ê´Â Igf2 À¯ÀüÀÚ¸¦ Ȱ¼ºÈ­ ½ÃÅ´ => ³­¸ð¼¼Æ÷¸¦ Á¤ÀÚ¼¼Æ÷È­ ÇÏ¿© ³­ÀÚ¿Í °áÇÕ½ÃÄÑ Ã³³à»ý½Ä Áã ź»ý ½ÃÅ´.
<formulas></formulas>
 
Áٱ⼼Æ÷.jpg

(4) 2007 ¾ß¸¶³ªÄ« ±³¼ö ÆÀ º¹¼öºÐÈ­´É À¯ÀüÀÚ µµÀÔÇÏ¿© ¼ºÃ¼¼¼Æ÷¸¦ ¹è¾ÆÁٱ⼼Æ÷È­
Oct3/4, Sox, Klf4, c-Myc À¯ÀüÀÚ¸¦ ¹ÙÀÌ·¯½º¸¦ ÀÌ¿ëÇØ ¼ºÃ¼¼¼Æ÷¿¡ ¡®Tranduction¡¯ÇÏ¿© À¯»ç ¹è¾ÆÁٱ⼼Æ÷¸¦ ¸¸µê
 
 
** iPS À¯ÀüÀÚ °ü·Ã
According to Yamanaka, the proteins encoded by these genes - identified from a pool of 24 candidates - each serve a specific role: c-Myc opens tightly compacted chromatin, enabling the transcription factors oct3/4 and sox2 to bind to gene regulatory regions in the genome and restore pluripotency. Klf4, he says, appears to fulfill two roles, both as a cofactor to oct3/4 and sox2, and as an apoptotic inhibitor.
 
** iPS ³í¶õ
(1) iPS methods may also produce quirks in cells, like so many booby traps - making the reprogrammed stem cells far too unpredictable, for now, to use in human therapy.
(2) Moreover, several of the genes used to trigger the reprogramming process are known to cause cancer in mammals.
(3) Retroviruses can disrupt the normal function of DNA and also can spur the birth of cancer cells.
 
Èñ¸Á»çÇ× : Harvard scientists, as well as biologists and ethicists from other institutions, argued forcefully that stem cells harvested from human embryos still represent the single best hope for ultimately treating humans with devastating ailments ranging from severed spinal cords to heart disease. Reprogrammed cells represent "a gigantic part of the future of stem cell research, but not the whole future,"
 
(2)(3) Retroviral vectors have been linked to leukemia in some gene therapy trials . a problem that is all the more acute because c-myc, at least, is a known oncogene. ¡°Because of that, I think using the retroviral system is very, in a sense, dangerous,¡± Yamanaka says.
 
 

 
   
 

ÀÌÀü È­¸éÀ¸·Î ´ÙÀ½À¸·Î   À§·Î
I ¾ö¸¶Æ°Æ° I ¿ù·Éº°À°¾Æ¹ý I ÀÌÀ¯½Ä I À°¾Æ¿ëǰ I ¿ù·Éº°³îÀ̹ý I À¯¾Æ±³À°°­Á I °Ç°­Á¤º¸ I ¾ÆÅäÇÇ I ¼îÇθô |
| ȸ»ç¼Ò°³ | ¼­ºñ½ºÀÌ¿ë¾à°ü | °³ÀÎÁ¤º¸Ãë±Þ¹æÄ§ | °í°´¼¾ÅÍ | ÀÌ¿ë¾È³» |
| »óÈ£ : ¿ì¸®¾Æ±â´åÄÄ | ÀüÈ­ : 02-848-0248 | ´ëÇ¥ : ¹é½Â¿î ¸ÞÀÏ | °³ÀÎÁ¤º¸°ü¸®Ã¥ÀÓÀÚ : À±ÀǼ÷ uryagi@naver.com | Hosting by ½ÉÇ÷º½ºÀÎÅͳÝ(ÁÖ) |
| ÁÖ¼Ò: ¼­¿ï½Ã ¿µµîÆ÷±¸ ´ë¸²µ¿ 865-1 4F | »ç¾÷ÀÚµî·Ï¹øÈ£ : 219-02-37779 | Åë½ÅÆÇ¸Å¾÷ : 2010-¼­¿ï¿µµîÆ÷-0137 | »ç¾÷ÀÚÁ¤º¸È®ÀÎ |
| Copyright ¨Ï 2000-2014 ¿ì¸®¾Æ±â´åÄÄ all rights reserved |
°ø±¸»óǰ
À±³²Åذ¡½À±â
\62,900
¹Ì¼³Á¤¹Ì±â
\350,000
ÇÏ¿ì½ëħ±¸
\229,000
·çÅ׸®À¯»ê±Õ
\67,500
º£ÀÌÆ÷ÀÌÁî
\69,000