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 건강 게시판 |
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아기 건강 |
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아기 신체 |
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아기가 아파요? |
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작성일 : 15-03-09 02:22
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글쓴이 :
우리아기
 조회 : 2,944
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 http://kimkwag.cafe24.com/stem_cell/Stemcell_sum.html [704] |
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2000 배아줄기세포주 NIH 에 등록(MzMedi)
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2004 Parthenogenic mouse(Kono)
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2006 쥐 유도복수분화줄기세포(Yamanaka)
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2007 Hwang’s SCNT-hESC-1 = Parthenote(Daley)
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Human iPS(Yamanaka, Daley)
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Cell Therapy(Transplantation Medicine) – 의학의 ‘Paradigm’을 바꾼다?
인간의 세포 종류 220 가지(210~274 kinds)
재생불능 세포 – 신경세포, 심근세포 (배아줄기세포 우선 적용 대상)
(1) 1998 윈슨콘신 대 Thomson 박사 팀의 인간배아줄기세포 생성
냉동수정란에서 배반포로 발생시켜 ICM을 꺼내 계대배양하여 hES cell 생성
(2) 2004 황교수 팀 체세포복제 인간배아줄기세포주 확립 주장
2007년 Laley 박사 보고서에서 단성생식배아줄기세포로 확실시 됨
(3) 2004 고노 박사 팀 처녀생식 쥐 탄생
정자세포에서 표현되지 않는 H19 유전자를 제거하고 난자에서 표현되지 않는 Igf2 유전자를 활성화 시킴 => 난모세포를 정자세포화 하여 난자와 결합시켜 처녀생식 쥐 탄생 시킴.
(4) 2007 야마나카 교수 팀 복수분화능 유전자 도입하여 성체세포를 배아줄기세포화
Oct3/4, Sox, Klf4, c-Myc 유전자를 바이러스를 이용해 성체세포에 ‘Tranduction’하여 유사 배아줄기세포를 만듦
According to Yamanaka, the proteins encoded by these genes - identified from a pool of 24 candidates - each serve a specific role: c-Myc opens tightly compacted chromatin, enabling the transcription factors oct3/4 and sox2 to bind to gene regulatory regions in the genome and restore pluripotency. Klf4, he says, appears to fulfill two roles, both as a cofactor to oct3/4 and sox2, and as an apoptotic inhibitor.
(1) iPS methods may also produce quirks in cells, like so many booby traps - making the reprogrammed stem cells far too unpredictable, for now, to use in human therapy.
(2) Moreover, several of the genes used to trigger the reprogramming process are known to cause cancer in mammals.
(3) Retroviruses can disrupt the normal function of DNA and also can spur the birth of cancer cells.
희망사항 : Harvard scientists, as well as biologists and ethicists from other institutions, argued forcefully that stem cells harvested from human embryos still represent the single best hope for ultimately treating humans with devastating ailments ranging from severed spinal cords to heart disease. Reprogrammed cells represent "a gigantic part of the future of stem cell research, but not the whole future,"
(2)(3) Retroviral vectors have been linked to leukemia in some gene therapy trials . a problem that is all the more acute because c-myc, at least, is a known oncogene. “Because of that, I think using the retroviral system is very, in a sense, dangerous,” Yamanaka says.
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